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For example, the inflammatory response to bacteria may be influenced by age,30 pres- ence of diabetes, tissue perfusion and oxygen- ation, other aspects of immunocompetence, and anti-inflammatory drug use.
This method is pain-free in patients with adequate tissue perfusion.
• alteration in the direction of fibroblast mi- gration, activation of cells in the wound site, improved tissue perfusion, and decreased edema.59
Numerous intrinsic factors affect the ability of the skin and supporting structures to respond to pressure and shear forces, including age, spinal cord injury, nutrition, and steroid administration; these factors are believed to affect collagen synthe- sis and degradation.16 Other intrinsic factors affect tissue perfusion, including systemic blood pressure, extracorporeal circulation, serum protein, smoking, hemoglobin and hematocrit, vascular disease, diabetes melli- tus, vasoactive drugs, and increases in body temperature.16
In normal states, arterial tissue perfusion is well above minimal requirements.
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